Inhibition of human immunodeficiency virus (HIV-1) infection in human peripheral blood leucocytes-SCID reconstituted mice by rapamycin

The capacity of the immunomodulatory drug rapamycin (RAPA) to inhibit replication of the CCR5 strain of human immunodeficiency virus (HIV) in vitro prompted us to test its effects in a murine preclinical model of HIV infection. RAPA (0·6 or 6 mg/kg body weight) or its vehicle were administered daily...

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Main Authors: Nicoletti, F, Lamenta, C, Donati, S, Spada, M, Ranazzi, A, Cacopardo, B, Mangano, K, Belardelli, F, Perno, C, Aquaro, S
格式: Artigo
語言:Inglês
出版: Blackwell Science Inc 2009
主題:
Translational Studies
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2665676/
https://ncbi.nlm.nih.gov/pubmed/19076826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2249.2008.03780.x
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