Transforming Growth Factor β Can Stimulate Smad1 Phosphorylation Independently of Bone Morphogenic Protein Receptors

Transforming growth factor-β (TGFβ) superfamily ligands control a diverse set of cellular processes by activating type I and type II serine-threonine receptor kinases. Canonical TGFβ signaling is mediated via the TβRI/ALK5 type I receptor that phosphorylates Smad2 and Smad3 in their SXS motif to fac...

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Bibliographic Details
Main Authors: Wrighton, Katharine H., Lin, Xia, Yu, Paul B., Feng, Xin-Hua
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Mechanisms of Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2665096/
https://ncbi.nlm.nih.gov/pubmed/19224917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M809223200
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