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Dimeric Quaternary Structure of the Prototypical Dual Specificity Phosphatase VH1

The Vaccinia virus H1 gene product, VH1, is a dual specificity phosphatase that down-regulates the cellular antiviral response by dephosphorylating STAT1. The crystal structure of VH1, determined at 1.32 Å resolution, reveals a novel dimeric quaternary structure, which exposes two active sites space...

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Bibliografski detalji
Glavni autori: Koksal, Adem C., Nardozzi, Jonathan D., Cingolani, Gino
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2009
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2665067/
https://ncbi.nlm.nih.gov/pubmed/19211553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M808362200
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