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Dimeric Quaternary Structure of the Prototypical Dual Specificity Phosphatase VH1
The Vaccinia virus H1 gene product, VH1, is a dual specificity phosphatase that down-regulates the cellular antiviral response by dephosphorylating STAT1. The crystal structure of VH1, determined at 1.32 Å resolution, reveals a novel dimeric quaternary structure, which exposes two active sites space...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2665067/ https://ncbi.nlm.nih.gov/pubmed/19211553 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M808362200 |
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