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Heterochronic Shift in Hox-Mediated Activation of Sonic hedgehog Leads to Morphological Changes during Fin Development

We explored the molecular mechanisms of morphological transformations of vertebrate paired fin/limb evolution by comparative gene expression profiling and functional analyses. In this study, we focused on the temporal differences of the onset of Sonic hedgehog (Shh) expression in paired appendages a...

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Main Authors: Sakamoto, Koji, Onimaru, Koh, Munakata, Keijiro, Suda, Natsuno, Tamura, Mika, Ochi, Haruki, Tanaka, Mikiko
格式: Artigo
語言:Inglês
出版: Public Library of Science 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2664896/
https://ncbi.nlm.nih.gov/pubmed/19365553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005121
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