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Copper(II) Binding to α-Synuclein, the Parkinson’s Protein
[Image: see text] Variations in tryptophan fluorescence intensities confirm that copper(II) interacts with α-synuclein, a protein implicated in Parkinson’s disease. Trp4 fluorescence decay kinetics measured for the F4W protein show that Cu(II) binds tightly (K(d) ∼ 100 nM) near the N-terminus at pH...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical Society
2008
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2664836/ https://ncbi.nlm.nih.gov/pubmed/18465859 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja711415b |
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