Spermine Binding to Parkinson’s Protein α-Synuclein and its Disease-Related A30P and A53T Mutants

The aggregation of α-synuclein (α-syn), a protein implicated in Parkinson’s disease (PD), is believed to progress through the formation of a partially folded intermediate. Using nano-electrospray ionization (ESI) mass spectrometry combined with ion mobility measurements we found evidence for a highl...

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Bibliografiske detaljer
Main Authors: Grabenauer, Megan, Bernstein, Summer L., Lee, Jennifer C., Wyttenbach, Thomas, Dupuis, Nicholas F., Gray, Harry B., Winkler, Jay R., Bowers, Michael T.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2639767/
https://ncbi.nlm.nih.gov/pubmed/18693700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp801175w
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