Diverse karyotypic abnormalities of the c-myc locus associated with c-myc dysregulation and tumor progression in multiple myeloma

Translocations involving c-myc and an Ig locus have been reported rarely in human multiple myeloma (MM). Using specific fluorescence in situ hybridization probes, we show complex karyotypic abnormalities of the c-myc or L-myc locus in 19 of 20 MM cell lines and approximately 50% of advanced primary...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Shou, Yaping, Martelli, Maria L., Gabrea, Ana, Qi, Ying, Brents, Leslie A., Roschke, Anna, Dewald, Gordon, Kirsch, Ilan R., Bergsagel, P. Leif, Kuehl, W. Michael
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2000
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC26645/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10618400/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.1.228
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