Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1- phosphatidylinositol 3-kinase complex

Beclin 1, a mammalian autophagy protein that is implicated in development, tumor suppression, neurodegeneration and cell death, exists in complex with Vps34, the class III phosphatidylinositol 3-kinase (PI-3K) that mediates multiple vesicle trafficking pathways including endocytosis and autophagy. H...

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Main Authors: Zhong, Yun, Wang, Qing Jun, Li, Xianting, Yan, Ying, Backer, Jonathan M., Chait, Brian T., Heintz, Nathaniel, Yue, Zhenyu
Format: Artigo
Jezik:Inglês
Izdano: 2009
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2664389/
https://ncbi.nlm.nih.gov/pubmed/19270693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb1854
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