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Native-like RNA tertiary structures using a sequence-encoded cleavage agent and refinement by discrete molecular dynamics

The difficulty of analyzing higher order RNA structure, especially for folding intermediates and for RNAs whose functions require domains that are conformationally flexible, emphasizes the need for new approaches for modeling RNA tertiary structure accurately. Here, we report a concise approach that...

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Detalhes bibliográficos
Main Authors: Gherghe, Costin M., Leonard, Christopher W., Ding, Feng, Dokholyan, Nikolay V., Weeks, Kevin M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2664099/
https://ncbi.nlm.nih.gov/pubmed/19193004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja805460e
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