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Neurodegeneration mutations in dynactin impair dynein-dependent nuclear migration

Neurodegenerative disease in humans and mice can be caused by mutations affecting the microtubule motor dynein or its biochemical regulator, dynactin, a multiprotein complex required for dynein function (1–4). A single amino acid change, G59S, in the conserved cytoskeletal-associated protein glycine...

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Detalhes bibliográficos
Main Authors: Moore, Jeffrey K., Sept, David, Cooper, John A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2664072/
https://ncbi.nlm.nih.gov/pubmed/19279216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0810828106
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