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Stimulated nuclear translocation of NF-κB and shuttling differentially depend on dynein and the dynactin complex

Translocation from the cytoplasm to the nucleus is required for the regulation of gene expression by transcription factors of the nuclear factor kappa B (NF-κB) family. The p65:p50 NF-κB heterodimer that predominates in many cell types can undergo stimulated movement, following degradation of the Iκ...

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Autors principals: Shrum, Cynthia K., DeFrancisco, Daniel, Meffert, Mollie K.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2650318/
https://ncbi.nlm.nih.gov/pubmed/19196984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0806677106
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