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Bilirubin and glutathione have complementary antioxidant and cytoprotective roles

Glutathione (GSH) and bilirubin are prominent endogenous antioxidant cytoprotectants. Despite tissue levels that are thousands of times lower than GSH, bilirubin is effective because of the biosynthetic cycle wherein it is generated from biliverdin by biliverdin reductase (BVR). When bilirubin acts...

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Detalhes bibliográficos
Main Authors: Sedlak, Thomas W., Saleh, Masoumeh, Higginson, Daniel S., Paul, Bindu D., Juluri, Krishna R., Snyder, Solomon H.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2664041/
https://ncbi.nlm.nih.gov/pubmed/19286972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0813132106
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