Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound

Canonical transient receptor potential (TRPC) channels control influxes of Ca(2+) and other cations that induce diverse cellular processes upon stimulation of plasma membrane receptors coupled to phospholipase C (PLC). Invention of subtype-specific inhibitors for TRPCs is crucial for distinction of...

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Detalhes bibliográficos
Main Authors: Kiyonaka, Shigeki, Kato, Kenta, Nishida, Motohiro, Mio, Kazuhiro, Numaga, Takuro, Sawaguchi, Yuichi, Yoshida, Takashi, Wakamori, Minoru, Mori, Emiko, Numata, Tomohiro, Ishii, Masakazu, Takemoto, Hiroki, Ojida, Akio, Watanabe, Kenta, Uemura, Aya, Kurose, Hitoshi, Morii, Takashi, Kobayashi, Tsutomu, Sato, Yoji, Sato, Chikara, Hamachi, Itaru, Mori, Yasuo
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2664023/
https://ncbi.nlm.nih.gov/pubmed/19289841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0808793106
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