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Organ-Specific Attenuation of Murine Hepatitis Virus Strain A59 by Replacement of Catalytic Residues in the Putative Viral Cyclic Phosphodiesterase ns2

The Murine hepatitis virus (MHV) strain A59 ns2 protein is a 30-kDa nonstructural protein that is expressed from a subgenomic mRNA in the cytoplasm of virus-infected cells. Its homologs are also encoded in other closely related group 2a coronaviruses and more distantly related toroviruses. Together,...

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Autori principali: Roth-Cross, Jessica K., Stokes, Helen, Chang, Guohui, Chua, Ming Ming, Thiel, Volker, Weiss, Susan R., Gorbalenya, Alexander E., Siddell, Stuart G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2663271/
https://ncbi.nlm.nih.gov/pubmed/19176619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02203-08
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