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A Grafting Strategy for the Design of Improved G-Quadruplex Aptamers and High-Activity DNAzymes
Nucleic acid aptamers are generally obtained by in vitro selection. Some have G-rich consensus sequences with ability to fold into the four-stranded structures known as G-quadruplexes. A few G-quadruplex aptamers have proven to bind hemin to form a new class of DNAzyme with the peroxidase-like activ...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2663033/ https://ncbi.nlm.nih.gov/pubmed/19357767 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005126 |
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