T-Bet Polymorphisms Are Associated with Asthma and Airway Hyperresponsiveness

Rationale: T-bet (TBX21 or T-box 21) is a critical regulator of T-helper 1 lineage commitment and IFN-γ production. Knockout mice lacking T-bet develop airway hyperresponsiveness (AHR) to methacholine, peribronchial eosinophilic and lymphocytic inflammation, and increased type III collagen depositio...

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Main Authors: Raby, Benjamin A., Hwang, Eun-Sook, Steen, Kristel Van, Tantisira, Kelan, Peng, Stanford, Litonjua, Augusto, Lazarus, Ross, Giallourakis, Cosmas, Rioux, John D., Sparrow, David, Silverman, Edwin K., Glimcher, Laurie H., Weiss, Scott T.
格式: Artigo
語言:Inglês
出版: American Thoracic Society 2006
主題:
B. Asthma and Allergy
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662983/
https://ncbi.nlm.nih.gov/pubmed/16179640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.200503-505OC
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