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Digital signaling and hysteresis characterize Ras activation in lymphoid cells
Activation of Ras proteins underlies functional decisions in diverse cell types. Two molecules, RasGRP and SOS, catalyze Ras activation in lymphocytes. Binding of active Ras to SOS′ allosteric pocket markedly increases SOS′ activity establishing a positive feedback loop for SOS-mediated Ras activati...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2662698/ https://ncbi.nlm.nih.gov/pubmed/19167334 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2008.11.051 |
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