Targeted generation of DNA strand breaks using pyrene-conjugated triplex-forming oligonucleotides

Gene targeting by triplex-forming oligonucleotides (TFOs) has proven useful for gene modulation in vivo. Photoreactive molecules have been conjugated to TFOs to direct sequence-specific damage in double-stranded DNA. However, the photoproducts are often repaired efficiently in cells. This limitation...

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Bibliographic Details
Main Authors: Benfield, Aaron P., Macleod, Michael C., Liu, Yaobin, Wu, Qi, Wensel, Theodore G., Vasquez, Karen M.
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662494/
https://ncbi.nlm.nih.gov/pubmed/18473480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi7024029
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