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Involvement of p38 MAPK in Regulation of MMP13 mRNA in Chondrocytes in Response to Surviving Stress to Endoplasmic Reticulum

MMP13 is enriched in mature chondrocytes and considered a prime cause of ECM degradation in the osteoarthritic articular cartilage in temporomandibular joints. We asked whether surviving stress to the endoplasmic reticulum (ER) would upregulate transcription of MMP13, and if so, whether a cross-talk...

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Autori principali: Hamamura, Kazunori, Goldring, Mary B., Yokota, Hiroki
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662326/
https://ncbi.nlm.nih.gov/pubmed/19100962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.archoralbio.2008.11.003
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