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Internal Core Protein Cleavage Leaves the Hepatitis B Virus Capsid Intact and Enhances Its Capacity for Surface Display of Heterologous Whole Chain Proteins

Virus capsids find increasing use as nanoparticulate platforms for the surface display of heterologous ligands, including as multivalent vaccine carriers. Presentation on the icosahedral hepatitis B virus capsid (HBcAg) is known to strongly enhance immunogenicity of foreign sequences, most efficient...

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主要な著者: Walker, Andreas, Skamel, Claudia, Vorreiter, Jolanta, Nassal, Michael
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2008
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662272/
https://ncbi.nlm.nih.gov/pubmed/18826949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805211200
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