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Internal Core Protein Cleavage Leaves the Hepatitis B Virus Capsid Intact and Enhances Its Capacity for Surface Display of Heterologous Whole Chain Proteins

Virus capsids find increasing use as nanoparticulate platforms for the surface display of heterologous ligands, including as multivalent vaccine carriers. Presentation on the icosahedral hepatitis B virus capsid (HBcAg) is known to strongly enhance immunogenicity of foreign sequences, most efficient...

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Hlavní autoři: Walker, Andreas, Skamel, Claudia, Vorreiter, Jolanta, Nassal, Michael
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662272/
https://ncbi.nlm.nih.gov/pubmed/18826949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805211200
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