Fbxw7 Acts as an E3 Ubiquitin Ligase That Targets c-Myb for Nemo-like Kinase (NLK)-induced Degradation

The c-myb proto-oncogene product (c-Myb) is degraded in response to Wnt-1 signaling via a pathway involving TAK1 (transforming growth factor-β-activated kinase 1), HIPK2 (homeodomain-interacting protein kinase 2), and NLK (Nemo-like kinase). NLK directly binds to c-Myb, which results in the phosphor...

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Main Authors: Kanei-Ishii, Chie, Nomura, Teruaki, Takagi, Tsuyoshi, Watanabe, Nobumoto, Nakayama, Keiichi I., Ishii, Shunsuke
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Protein Synthesis, Post-Translational Modification, and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662147/
https://ncbi.nlm.nih.gov/pubmed/18765672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804340200
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