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Degradation of the endoplasmic reticulum–anchored transcription factor MyRF by the ubiquitin ligase SCF(Fbxw7) in a manner dependent on the kinase GSK-3

The ubiquitin-proteasome system regulates the abundance of many cellular proteins by mediating their targeted degradation. We previously developed a method—differential proteomics–based identification of ubiquitylation substrates (DiPIUS)—for the comprehensive identification of substrates for a give...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Nakayama, Shogo, Yumimoto, Kanae, Kawamura, Atsuki, Nakayama, Keiichi I.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5900774/
https://ncbi.nlm.nih.gov/pubmed/29472293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000741
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