The Crystal Structure of Thrombin-activable Fibrinolysis Inhibitor (TAFI) Provides the Structural Basis for Its Intrinsic Activity and the Short Half-life of TAFIa

Mature thrombin-activable fibrinolysis inhibitor (TAFIa) is a highly unstable metallocarboxypeptidase that stabilizes blood clots by clipping C-terminal lysine residues from partially degraded fibrin. In accordance with its in vitro antifibrinolytic activity, animal studies have reported that inhibi...

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Detalhes bibliográficos
Main Authors: Anand, Kanchan, Pallares, Irantzu, Valnickova, Zuzana, Christensen, Trine, Vendrell, Josep, Wendt, K. Ulrich, Schreuder, Herman A., Enghild, Jan J., Avilés, Francesc X.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662027/
https://ncbi.nlm.nih.gov/pubmed/18669641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804003200
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