The G(i)-coupled P2Y12 Receptor Regulates Diacylglycerol-mediated Signaling in Human Platelets

Stimulation of G(q)-coupled receptors activates phospholipase C and is supposed to promote both intracellular Ca(2+) mobilization and protein kinase C (PKC) activation. We found that ADP-induced phosphorylation of pleckstrin, the main platelet substrate for PKC, was completely inhibited not only by...

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Detalhes bibliográficos
Main Authors: Guidetti, Gianni F., Lova, Paolo, Bernardi, Bruno, Campus, Francesca, Baldanzi, Gianluca, Graziani, Andrea, Balduini, Cesare, Torti, Mauro
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2661997/
https://ncbi.nlm.nih.gov/pubmed/18755689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801588200
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