Pharmacokinetic interaction of flecainide and paroxetine in relation to the CYP2D6*10 allele in healthy Korean subjects

AIMS: The objectives were to evaluate the effect of CYP2D6 genetic polymorphism on the pharmacokinetics of flecainide, and also on the extent of drug interaction with paroxetine as a CYP2D6 inhibitor after a single oral administration in healthy subjects. METHODS: An open-label, two-period, single-s...

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Hauptverfasser: Lim, Kyoung Soo, Cho, Joo-Youn, Jang, In-Jin, Kim, Bo-Hyung, Kim, JaeWoo, Jeon, Ji-Young, Tae, Yu-Mi, Yi, SoJeong, Eum, SoYoung, Shin, Sang-Goo, Yu, Kyung-Sang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Blackwell Science Inc 2008
Schlagworte:
Pharmacogenetics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2661981/
https://ncbi.nlm.nih.gov/pubmed/18754843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2008.03267.x
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