Flexible dosing of Tincture of Opium in the management of opioid withdrawal: pharmacokinetics and pharmacodynamics

AIMS: The aim was to evaluate the clinical effectiveness, pharmacodynamics and pharmacokinetics of a range of Tincture of Opium (TOP) doses in the management of opioid withdrawal. METHODS: Forty-five opium-dependent Thai subjects were allocated to three dosing groups (6.66, 13.3 and 20 mg morphine e...

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Autori principali: Somogyi, Andrew A, Larsen, Mie, Abadi, Reza M, Jittiwutikarn, Jaroon, Ali, Robert, White, Jason M
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Science Inc 2008
Soggetti:
Pharmacokinetic Dynamic Relationships
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2661979/
https://ncbi.nlm.nih.gov/pubmed/19032172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2008.03277.x
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