Determination of a benzamide histone deacetylase inhibitor, MS-275, in human plasma by liquid chromatography with mass-spectrometric detection

An analytical method was developed and validated for the quantitative determination of the histone deacetylase inhibitor MS-275 in human plasma. Calibration curves were linear in the concentration range of 1 to 250 ng/mL. Sample pretreatment involved a liquid-liquid extraction of 0.1 mL aliquots of...

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Bibliographic Details
Main Authors: Danish, Matthew, Gardner, Erin R., Chen, Xiaohong, Figg, William D.
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2661872/
https://ncbi.nlm.nih.gov/pubmed/19117815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jchromb.2008.12.018
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