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Inactive conformation of the serpin α(1)-antichymotrypsin indicates two-stage insertion of the reactive loop: Implications for inhibitory function and conformational disease

The serpins are a family of proteinase inhibitors that play a central role in the control of proteolytic cascades. Their inhibitory mechanism depends on the intramolecular insertion of the reactive loop into β-sheet A after cleavage by the target proteinase. Point mutations within the protein can al...

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Bibliografiske detaljer
Main Authors: Gooptu, Bibek, Hazes, Bart, Chang, Wun-Shaing W., Dafforn, Timothy R., Carrell, Robin W., Read, Randy J., Lomas, David A.
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 2000
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC26617/
https://ncbi.nlm.nih.gov/pubmed/10618372
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