Structural interactions of fibroblast growth factor receptor with its ligands

Fibroblast growth factors (FGFs) effect cellular responses by binding to FGF receptors (FGFRs). FGF bound to extracellular domains on the FGFR in the presence of heparin activates the cytoplasmic receptor tyrosine kinase through autophosphorylation. We have crystallized a complex between human FGF1...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Stauber, Deborah J., DiGabriele, Anna D., Hendrickson, Wayne A.
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 2000
Sujets:	Biological Sciences
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC26614/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10618369/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.1.49
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