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Structural interactions of fibroblast growth factor receptor with its ligands

Fibroblast growth factors (FGFs) effect cellular responses by binding to FGF receptors (FGFRs). FGF bound to extracellular domains on the FGFR in the presence of heparin activates the cytoplasmic receptor tyrosine kinase through autophosphorylation. We have crystallized a complex between human FGF1...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Stauber, Deborah J., DiGabriele, Anna D., Hendrickson, Wayne A.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2000
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC26614/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10618369/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.1.49
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