The O(2) sensitivity of the transcription factor FNR is controlled by Ser24 modulating the kinetics of [4Fe-4S] to [2Fe-2S] conversion

Fumarate and nitrate reduction regulatory (FNR) proteins are bacterial transcription factors that coordinate the switch between aerobic and anaerobic metabolism. In the absence of O(2), FNR binds a [4Fe-4S](2+) cluster (ligated by Cys-20, 23, 29, 122) promoting the formation of a transcriptionally a...

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Autori principali: Jervis, Adrian J., Crack, Jason C., White, Gaye, Artymiuk, Peter J., Cheesman, Myles R., Thomson, Andrew J., Le Brun, Nick E., Green, Jeffrey
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2009
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2660729/
https://ncbi.nlm.nih.gov/pubmed/19261852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0804943106
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