Simvastatin enhances bone marrow stromal cell differentiation into endothelial cells via notch signaling pathway

Bone marrow stromal cells (BMSCs) are capable of differentiating into multiple cell lineages including endothelial cells. Simvastatin, an HMG-CoA reductase inhibitor that is used as a cholesterol-lowering agent, promotes endothelial differentiation from epithelial progenitor cells (EPC). The Notch s...

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Bibliographic Details
Main Authors: Xu, Jian, Liu, Xinfeng, Chen, Jieli, Zacharek, Alex, Cui, Xu, Savant-Bhonsale, Smita, Liu, Zhenguo, Chopp, Michael
Format: Artigo
Language:Inglês
Published: American Physiological Society 2009
Subjects:
Growth, Differentiation, and Apoptosis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2660258/
https://ncbi.nlm.nih.gov/pubmed/19109527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00310.2008
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