Simvastatin enhances bone marrow stromal cell differentiation into endothelial cells via notch signaling pathway

Bone marrow stromal cells (BMSCs) are capable of differentiating into multiple cell lineages including endothelial cells. Simvastatin, an HMG-CoA reductase inhibitor that is used as a cholesterol-lowering agent, promotes endothelial differentiation from epithelial progenitor cells (EPC). The Notch s...

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Autores principales: Xu, Jian, Liu, Xinfeng, Chen, Jieli, Zacharek, Alex, Cui, Xu, Savant-Bhonsale, Smita, Liu, Zhenguo, Chopp, Michael
Formato: Artigo
Lenguaje:Inglês
Publicado: American Physiological Society 2009
Materias:
Growth, Differentiation, and Apoptosis
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2660258/
https://ncbi.nlm.nih.gov/pubmed/19109527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00310.2008
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