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A T cell-dependent mechanism for the induction of human mucosal homing IgA-secreting plasmablasts

Mucosal IgA secreted by local plasma cells (PCs) is a critical component of mucosal immunity. Although IgA class switching can occur at mucosal sites, high-affinity PCs are optimally generated in germinal centers (GCs) in a T cell-dependent fashion. However, the mechanism of how CD4(+) helper T cell...

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Bibliographische Detailangaben
Hauptverfasser: Dullaers, Melissa, Li, Dapeng, Xue, Yaming, Ni, Ling, Gayet, Ingrid, Morita, Rimpei, Ueno, Hideki, Palucka, Karolina Anna, Banchereau, Jacques, Oh, SangKon
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2659635/
https://ncbi.nlm.nih.gov/pubmed/19144318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2008.11.008
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