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A T cell-dependent mechanism for the induction of human mucosal homing IgA-secreting plasmablasts
Mucosal IgA secreted by local plasma cells (PCs) is a critical component of mucosal immunity. Although IgA class switching can occur at mucosal sites, high-affinity PCs are optimally generated in germinal centers (GCs) in a T cell-dependent fashion. However, the mechanism of how CD4(+) helper T cell...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2009
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2659635/ https://ncbi.nlm.nih.gov/pubmed/19144318 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2008.11.008 |
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