Serum from patients with SLE instructs monocytes to promote IgG and IgA plasmablast differentiation

The development of autoantibodies is a hallmark of systemic lupus erythematosus (SLE). SLE serum can induce monocyte differentiation into dendritic cells (DCs) in a type I IFN–dependent manner. Such SLE-DCs activate T cells, but whether they promote B cell responses is not known. In this study, we d...

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Detalhes bibliográficos
Main Authors: Joo, HyeMee, Coquery, Christine, Xue, Yaming, Gayet, Ingrid, Dillon, Stacey R., Punaro, Marilynn, Zurawski, Gerard, Banchereau, Jacques, Pascual, Virginia, Oh, SangKon
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3405503/
https://ncbi.nlm.nih.gov/pubmed/22689824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20111644
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