HIGHLY DIASTEREOSELECTIVE SYNTHESIS OF NUCLEOSIDE ADDUCTS FROM THE CARCINOGENIC BENZO[a]PYRENE DIOL EPOXIDE AND A COMPUTATIONAL ANALYSIS

A diastereoselective synthesis of the nucleoside adducts corresponding to a cis ring opening of the carcinogen (±)-7β,8α-dihydroxy-9α,10α-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BaP DE-2) by 2’-deoxyadenosine and 2’-deoxyguanosine is described. The key intermediate (±)-10α-amino-7β,8α,9α-trihydroxy...

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Detalhes bibliográficos
Main Authors: Lakshman, Mahesh K., Keeler, John C., Ngassa, Felix N., Hilmer, John H., Pradhan, Padmanava, Zajc, Barbara, Thomasson, Kathryn A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2659345/
https://ncbi.nlm.nih.gov/pubmed/17199284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja063902u
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