Cowhage-Evoked Itch Is Mediated by a Novel Cysteine Protease: A Ligand of Protease-Activated Receptors

Cowhage spicules provide an important model for histamine-independent itch. We determined that the active component of cowhage, termed mucunain, is a novel cysteine protease. We isolated mucunain and demonstrate that both native and recombinant mucunain evoke the same quality of itch in humans. We a...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Reddy, Vemuri B., Iuga, Aurel O., Shimada, Steve G., LaMotte, Robert H., Lerner, Ethan A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Society for Neuroscience 2008
Pynciau:
Brief Communications
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2659338/
https://ncbi.nlm.nih.gov/pubmed/18434511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0716-08.2008
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