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Mutations at serine 37 in mouse guanylate kinase confer resistance to 6-thioguanine
Guanylate kinase (GMK) is an essential nucleoside monophosphate kinase that catalyzes the phosphorylation of guanine-monophosphate (GMP) and dGMP to yield GDP and dGDP, respectively, important precursors for nucleotide synthesis. GMK is also responsible for the activation of 6-thioguanine (6-TG), a...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2659005/ https://ncbi.nlm.nih.gov/pubmed/19136674 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzn078 |
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