BCRP expression does not result in resistance to STX140 in vivo, despite the increased expression of BCRP in A2780 cells in vitro after long-term STX140 exposure

The anti-proliferative and anti-angiogenic properties of the endogenous oestrogen metabolite, 2-methoxyoestradiol (2-MeOE2), are enhanced in a series of sulphamoylated derivatives of 2-MeOE2. To investigate possible mechanisms of resistance to these compounds, a cell line, A2780.140, eightfold less...

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Detalhes bibliográficos
Main Authors: Day, J M, Foster, P A, Tutill, H J, Newman, S P, Ho, Y T, Leese, M P, Potter, B V L, Reed, M J, Purohit, A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2658539/
https://ncbi.nlm.nih.gov/pubmed/19156141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6604873
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