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Down-regulation of Active ACK1 Is Mediated by Association with the E3 Ubiquitin Ligase Nedd4-2

ACK1 (activated Cdc42-associated kinase 1) is a cytoplasmic tyrosine kinase implicated in trafficking through binding to epidermal growth factor (EGF) receptor and clathrin. Here, we have identified a new ACK1-binding partner, the E3 ubiquitin ligase Nedd4-2, which binds ACK1 via a conserved PPXY-co...

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Detalhes bibliográficos
Main Authors: Chan, Wing, Tian, Rui, Lee, Yeow-Fong, Sit, Soon Tuck, Lim, Louis, Manser, Ed
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2658111/
https://ncbi.nlm.nih.gov/pubmed/19144635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806877200
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