Pneumocystis Mediates Overexpression of Antizyme Inhibitor Resulting in Increased Polyamine Levels and Apoptosis in Alveolar Macrophages

Pneumocystis pneumonia (PcP) is the most common opportunistic disease in immunocompromised patients. Alveolar macrophages are responsible for the clearance of Pneumocystis organisms; however, they undergo a high rate of apoptosis during PcP due to increased intracellular polyamine levels. In this st...

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Hlavní autoři: Liao, Chung-Ping, Lasbury, Mark E., Wang, Shao-Hung, Zhang, Chen, Durant, Pamela J., Murakami, Yasuko, Matsufuji, Senya, Lee, Chao-Hung
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2009
Témata:
Molecular Basis of Cell and Developmental Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2658110/
https://ncbi.nlm.nih.gov/pubmed/19158080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805787200
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