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Pneumocystis Mediates Overexpression of Antizyme Inhibitor Resulting in Increased Polyamine Levels and Apoptosis in Alveolar Macrophages

Pneumocystis pneumonia (PcP) is the most common opportunistic disease in immunocompromised patients. Alveolar macrophages are responsible for the clearance of Pneumocystis organisms; however, they undergo a high rate of apoptosis during PcP due to increased intracellular polyamine levels. In this st...

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Detalhes bibliográficos
Main Authors: Liao, Chung-Ping, Lasbury, Mark E., Wang, Shao-Hung, Zhang, Chen, Durant, Pamela J., Murakami, Yasuko, Matsufuji, Senya, Lee, Chao-Hung
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2658110/
https://ncbi.nlm.nih.gov/pubmed/19158080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805787200
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