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Pneumocystis Mediates Overexpression of Antizyme Inhibitor Resulting in Increased Polyamine Levels and Apoptosis in Alveolar Macrophages

Pneumocystis pneumonia (PcP) is the most common opportunistic disease in immunocompromised patients. Alveolar macrophages are responsible for the clearance of Pneumocystis organisms; however, they undergo a high rate of apoptosis during PcP due to increased intracellular polyamine levels. In this st...

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Autors principals: Liao, Chung-Ping, Lasbury, Mark E., Wang, Shao-Hung, Zhang, Chen, Durant, Pamela J., Murakami, Yasuko, Matsufuji, Senya, Lee, Chao-Hung
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2658110/
https://ncbi.nlm.nih.gov/pubmed/19158080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805787200
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