Polyamine Transport as a Target for Treatment of Pneumocystis Pneumonia

Polyamine levels are greatly increased in alveolar macrophages (AMs) during Pneumocystis pneumonia (PCP), leading to increased production of H(2)O(2), which causes AMs to undergo apoptosis. One of the mechanisms by which polyamine levels in AMs are elevated is enhanced uptake of exogenous polyamines...

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Detalhes bibliográficos
Main Authors: Liao, Chung-Ping, Phanstiel, Otto, Lasbury, Mark E., Zhang, Chen, Shao, Shoujin, Durant, Pamela J., Cheng, Bi-Hua, Lee, Chao-Hung
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2786323/
https://ncbi.nlm.nih.gov/pubmed/19805570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00662-09
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