Potentiation of Amyotrophic Lateral Sclerosis (ALS)-associated TDP-43 Aggregation by the Proteasome-targeting Factor, Ubiquilin 1

TDP-43 (43-kDa TAR DNA-binding domain protein) is a major constituent of ubiquitin-positive cytoplasmic aggregates present in neurons of patients with fronto-temporal lobular dementia and amyotrophic lateral sclerosis (ALS). The pathologic significance of TDP-43 aggregation is not known; however, do...

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Detalhes bibliográficos
Main Authors: Kim, Sang Hwa, Shi, Yuling, Hanson, Keith A., Williams, Leah M., Sakasai, Ryo, Bowler, Michael J., Tibbetts, Randal S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Protein Synthesis, Post-Translational Modification, and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2658102/
https://ncbi.nlm.nih.gov/pubmed/19112176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M808064200
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