Sulfonylurea Receptor 1 Mutations That Cause Opposite Insulin Secretion Defects with Chemical Chaperone Exposure

The β-cell ATP-sensitive potassium (K(ATP)) channel composed of sulfonylurea receptor SUR1 and potassium channel Kir6.2 serves a key role in insulin secretion regulation by linking glucose metabolism to cell excitability. Mutations in SUR1 or Kir6.2 that decrease channel function are typically assoc...

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Detaylı Bibliyografya
Asıl Yazarlar: Pratt, Emily B., Yan, Fei-Fei, Gay, Joel W., Stanley, Charles A., Shyng, Show-Ling
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2009
Konular:
Membrane Transport, Structure, Function, and Biogenesis
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2658088/
https://ncbi.nlm.nih.gov/pubmed/19151370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807012200
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