Disruption of a Plasmodium falciparum Multidrug Resistance-associated Protein (PfMRP) Alters Its Fitness and Transport of Antimalarial Drugs and Glutathione

ATP-binding cassette transporters play an important role in drug resistance and nutrient transport. In the human malaria parasite Plasmodium falciparum, a homolog of the human p-glycoprotein (PfPgh-1) was shown to be involved in resistance to several drugs. More recently, many transporters were asso...

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Detalhes bibliográficos
Main Authors: Raj, Dipak Kumar, Mu, Jianbing, Jiang, Hongying, Kabat, Juraj, Singh, Subash, Sullivan, Margery, Fay, Michael P., McCutchan, Thomas F., Su, Xin-zhuan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Membrane Transport, Structure, Function, and Biogenesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2658063/
https://ncbi.nlm.nih.gov/pubmed/19117944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806944200
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