Identification and Characterization of a Non-retinoid Ligand for Retinol-binding Protein 4 Which Lowers Serum Retinol-binding Protein 4 Levels in Vivo

Retinol-binding protein 4 (RBP4) transports retinol from the liver to extrahepatic tissues, and RBP4 lowering is reported to improve insulin sensitivity in mice. We have identified A1120, a high affinity (K(i) = 8.3 nm) non-retinoid ligand for RBP4, which disrupts the interaction between RBP4 and it...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Motani, Alykhan, Wang, Zhulun, Conn, Marion, Siegler, Karen, Zhang, Ying, Liu, Qingxiang, Johnstone, Sheree, Xu, Haoda, Thibault, Steve, Wang, Yingcai, Fan, Pingchen, Connors, Richard, Le, Hoa, Xu, Guifen, Walker, Nigel, Shan, Bei, Coward, Peter
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Biochemistry and Molecular Biology 2009
Θέματα:
Metabolism and Bioenergetics
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2658061/
https://ncbi.nlm.nih.gov/pubmed/19147488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M809654200
Ετικέτες: Προσθήκη ετικέτας
Δεν υπάρχουν, Καταχωρήστε ετικέτα πρώτοι!

Παρόμοια τεκμήρια