Biochemical, Functional, and Pharmacological Characterization of AT-56, an Orally Active and Selective Inhibitor of Lipocalin-type Prostaglandin D Synthase

We report here that 4-dibenzo[a,d]cyclohepten-5-ylidene-1-[4-(2H-tetrazol-5-yl)-butyl]-piperidine (AT-56) is an orally active and selective inhibitor of lipocalin-type prostaglandin (PG) D synthase (L-PGDS). AT-56 inhibited human and mouse L-PGDSs in a concentration (3–250 μm)-dependent manner but d...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Irikura, Daisuke, Aritake, Kosuke, Nagata, Nanae, Maruyama, Toshihiko, Shimamoto, Shigeru, Urade, Yoshihiro
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Enzyme Catalysis and Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2658056/
https://ncbi.nlm.nih.gov/pubmed/19131342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M808593200
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados